XXXII Annual Meeting of the Catalan Society of Nephrology

Date:Wednesday, 18 de May del 2016 Author:Meritxell Soria

The XXXII Annual Meeting of the Catalan Society of Nephrology, which will take place on 2 and 3 June in Castelldefels, has accepted our oral submission by professionals UDETMA unit, the Department of Nephrology of the University Hospital Arnau de Vilanova and Biomedical Research Institute of Lleida Foundation Dr. Pifarré (IRBLleida). The presentation will be on Friday 3 June from 8.30 to 10.00.

Summary:
The advanced glycation end products (AGEs), classically associated with type 2 diabetes, can estimate cardiovascular risk and vascular age. In the absence of hyperglycemia, AGEs can increase in the presence of oxidative stress and inflammation. Subcutaneous far AGEs is a quick, easy and safe technique. No information AGEs levels in early stages of kidney disease. Objective: To analyze the levels of AGEs in patients with kidney disease. Methods: An observational case-control study. It Includes: 87 individuals with stage 2, 3a and 3b kidney disease, and 87 without renal disease, matched for age, sex, BMI, waist circumference and smoking. Diabetics are excluded. The concentration of AGEs is obtained by skin autofluorescence (SAF) through an AGE Reader (DiagnOptics Technologies, Netherlands) multiple linear .Regressió to determine the factors associated with high levels of AGEs. Results: No statistically significant differences in age, sex and cardiovascular risk factors between the two groups. Patients with kidney disease had levels of SAF higher than the control group (2.2 ± 0.4 vs. 2.5 ± 0.6; p <0.001). The estimated vascular age was 12 years greater in patients with renal disease (p = 0.001). In the univariate analysis, SAF was negatively correlated with the glomerular filtration rate (r = -0.312, p = 0.003) and positively correlated with age (r = 0.586, p <0.001), pulse pressure (r = 0.380, p < 0.001) and SCORE (r = 0.434, p <0.001). Multiple linear regression showed that age and glomerular filtration rate are independently associated with SAF values ​​(p <0.001). Conclusions: AGEs are increased in early stages of kidney disease and increase as decreasing glomerular filtration. Patients with renal vascular disease are age 12 years longer than chronological age. This early vascular aging could favor future cardiovascular events. The measurement of AGEs, appears as a useful tool for assessing cardiovascular risk in kidney patients.